Ultrastructural localization of sorcin, a 22 kDa calcium binding protein, in the rat caudate-putamen nucleus: Association with ryanodine receptors and intracellular calcium release

1997 ◽  
Vol 386 (4) ◽  
pp. 625-634 ◽  
Author(s):  
Virginia M. Pickel ◽  
Catherine L. Clarke ◽  
Marian B. Meyers
Keyword(s):  
Intracellular Calcium ◽  
Calcium Binding ◽  
Calcium Release ◽  
Binding Protein ◽  
Ryanodine Receptors ◽  
Ultrastructural Localization ◽  
Calcium Binding Protein ◽  
Caudate Putamen ◽  
Intracellular Calcium Release

scholarly journals Increased Susceptibility to Isoproterenol-Induced Cardiac Hypertrophy and Impaired Weight Gain in Mice Lacking the Histidine-Rich Calcium-Binding Protein

2006 ◽  
Vol 26 (24) ◽  
pp. 9315-9326 ◽  
Author(s):  
Eric J. Jaehnig ◽  
Analeah B. Heidt ◽  
Stephanie B. Greene ◽  
Ivo Cornelissen ◽  
Brian L. Black
Keyword(s):  
Weight Gain ◽  
Cardiac Hypertrophy ◽  
Knockout Mice ◽  
Calcium Binding ◽  
Calcium Release ◽  
Binding Protein ◽  
Critical Role ◽  
Calcium Binding Protein ◽  
Calcium Handling

ABSTRACT The sarcoplasmic reticulum (SR) plays a critical role in excitation-contraction coupling by regulating the cytoplasmic calcium concentration of striated muscle. The histidine-rich calcium-binding protein (HRCBP) is expressed in the junctional SR, the site of calcium release from the SR. HRCBP is expressed exclusively in muscle tissues and binds calcium with low affinity and high capacity. In addition, HRCBP interacts with triadin, a protein associated with the ryanodine receptor and thought to be involved in calcium release. Its calcium binding properties, localization to the SR, and interaction with triadin suggest that HRCBP is involved in calcium handling by the SR. To determine the function of HRCBP in vivo, we inactivated HRC, the gene encoding HRCBP, in mice. HRC knockout mice exhibited impaired weight gain beginning at 11 months of age, which was marked by reduced skeletal muscle and fat mass, and triadin protein expression was upregulated in the heart of HRC knockout mice. In addition, HRC null mice displayed a significantly exaggerated response to the induction of cardiac hypertrophy by isoproterenol compared to their wild-type littermates. The exaggerated response of HRC knockout mice to the induction of cardiac hypertrophy is consistent with a regulatory role for HRCBP in calcium handling in vivo and suggests that mutations in HRC, in combination with other genetic or environmental factors, might contribute to pathological hypertrophy and heart failure.

Identification and ultrastructural localization of a calretinin-like calcium-binding protein (protein 10) in the guinea pig and rat inner ear

1991 ◽  
Vol 560 (1-2) ◽  
pp. 139-148 ◽  
Author(s):  
Claude J. Dechesne ◽  
Lois Winsky ◽  
Hong N. Kim ◽  
Gertrude Goping ◽  
Thuc D. Vu ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
Calcium Binding ◽  
Binding Protein ◽  
Ultrastructural Localization ◽  
Calcium Binding Protein

Intracellular calcium-binding protein S100A4 influences injury-induced migration of white matter astrocytes

2006 ◽  
Vol 111 (3) ◽  
pp. 213-219 ◽  
Author(s):  
Z. Fang ◽  
N. Duthoit ◽  
G. Wicher ◽  
Ö. Källskog ◽  
N. Ambartsumian ◽  
...  
Keyword(s):  
White Matter ◽  
Intracellular Calcium ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein
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